Climbing up towards the Great St Bernard Pass, the first centre you come to is Gignod, which features a picturesque church with a Gothic entrance.
Continuing the ascent, you reach the mediaeval village of Étroubles, and a few kilometres further on, you pass through Saint-Oyen, a small village with traditional Val d’Aosta style houses.
At the foot of the main village, you can see the Great St Bernard charitable home run by monks, and the Regina Pacis monastery.

The last municipality on the Italian side is Saint-Rhémy-en-Bosses, famous for its DOP raw ham called “Vallée d’Aoste Jambon de Bosses”.
Before entering the village, you turn right onto the road which, in 10 kilometres, leads you to the Great St Bernard Pass. The Celts, the Romans and, from the Middle Ages, numerous pilgrims who traveled the Via Francigena in the direction of Rome passed through this Alpine pass. The most famous crossing was that made by Napoleon. Just a few metres across the Pass, on the Swiss side, stands the famous hospice where they breeded St Bernard dogs.

Places you go through on the route:
- Aosta (590 m)
- Arpuilles junction 1.9 km (690 m)
- Valpelline junction 3.8 km (780 m)
- Gignod 8 km (960 m)
- Etroubles 16.4 km (1,265 m)
- Saint-Oyen 18.1 km (1,350 m)
- Great St Bernard Pass junction 20.3 km (1,490 m)
- Saint-Rhémy 22.2 km (1,615 m)
- Great St Bernard Pass 35.1 km (2,473 m)

Route included in a stage of the Giro d’Italia in 1973 (Geneva/Aosta). Stage won by Merckx (Belgium).
Passage of the 13th stage of the Giro d’Italia 2023 from Borgofranco d’Ivrea to Crans-Montana, where the Great St Bernard Pass is the “Cima Coppi”, i.e. the highest point of the whole competition.